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Title: Effect of microsomal enzyme inducers and inhibitors on the toxicity of tunicamycin and corynetoxis, the causal agent of annual ryegrass toxicity / Paul Vogel, Zoe L. Ellis and Jennifer J. Carlin.
Author: Vogel, P. (Western Australia Dept. of Agriculture, Perth. Animal Health Laboratory) ; Ellis, Z. E. (Western Australia Dept. of Agriculture, Perth. Animal Health Laboratory) ; Carlin, J. J. (Western Australia Dept. of Agriculture, Perth. Animal Health Laboratory)
Year: 1986.
Series: Veterinary and Human Toxicology (U.S.A.), v. 28(6)
Description: p. 530-532.
Subject: Annual ryegrass toxicity. ; Corynebacterium. ; Tunicamycin.
Notes: Photocopy only. 2 tables.
18 ref.
(En)
Type: Book
Abstract: (En)
Of the microsomal enzyme inducers and inhibitors tested in rats, the only one to modify the toxicity of tunicamycin or the closely-related corynetoxin, the causal agent of annual ryegrass toxicity, was phenobarbitone. It increased the LD50 of tunicamycin from 0.31 mg/kg to 0.77 mg/kg. Similar results were obtained with the related corynetoxin. Tunicamycin was also shown to be an inhibitor of cytochromes P-450. Rats sacrificed 48 h after receiving an LD50 dose of tunicamycin had cytochroms P-450 levels
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